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SCIENCE

PDRN, made without animal-derived sources

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Advancing PDRN across five fields of human biology

Dermatology

Preclinical

We are investigating PDRN in burns, wounds that are slow to close, ageing skin and hair regrowth.

ResearchPreclinicalClinicalApproved

Orthopaedics

Research

We are investigating PDRN in knee osteoarthritis, tendon injury and delayed bone healing.

ResearchPreclinicalClinicalApproved

Cardiology

Research

We are investigating PDRN in impaired circulation of the lower limbs and diabetic foot ulcers.

ResearchPreclinicalClinicalApproved

Gastroenterology

Research

We are investigating PDRN in inflammatory bowel disease and periodontal disease.

ResearchPreclinicalClinicalApproved

Neurology

Research

We are investigating PDRN in carpal tunnel syndrome and persistent neuropathic pain following injury.

ResearchPreclinicalClinicalApproved

Each programme is shown at the stage it has reached today. No Synthena PDRN programme has entered clinical trials, and no Synthena PDRN medicine has been approved for any indication.

OUR APPROACH

A focus on building blocks the body already uses

Every cell relies on nucleotides to build and repair its DNA. Research suggests that as PDRN is broken down, its components can enter nucleotide salvage pathways. We are developing PDRN without animal-derived starting material, with tight control over the length of the DNA fragments we produce.

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THE MOLECULE

A narrower, defined range

Our target fragments are 20–80 base pairs, approximately 13–53 kilodaltons. PDRN described in the scientific literature commonly spans a much broader range.

READ MORE:
  • Chae et al., 2025
  • Squadrito et al., 2017
  • Galeano et al., 2021
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HOW IT IS MADE

From defined material to medicine

Through control over how PDRN is made, we aim to bring a defined, consistent material from the bench toward medicines that can change patients' lives.

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OUR STANDARD

A number never stands alone.

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Making medicine from the building blocks of life

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